Scientific Papers

Original Scientific Findings Relating to Q-Cells®
 
  1. Haas and Fischer (2013) Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. J Neurotrauma 30:1-18
  2. Kim et al (2012) ICV-Transplanted human glial precursor cells are short-lived yet exert immunomodulatory effects in mice with EAE.Glia 60:117-1129
  3. Lepore et al (2011) Human glial-restricted progenitor transpantation into cervical spinal cord of the SOD1G93A mouse model of ALS. PLoS One 6(10): e25968
  4. Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination. Walczak P, All AH, Rumpal N, Gorelik M, Kim H, Maybhate A, Agrawal G, Campanelli JT, Gilad AA, Kerr DA, Bulte JW. Glia 2011 Mar;59(3):499-510. doi: 10.1002/glia.21119. Epub 2010 Dec 29
  5. Jin et al (2011)Transplantation of Human Glial Restricted Progenitors and Derived Astrocytes into a Contusion Model of Spinal Cord Injury. Jin et al, J Neurotrauma 28:579-594
  6. Sandrock et al (2010) Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neurological disorders.  Regen Med. 2010 May 5(3): 381-94
  7. Transplantation of Human Glial Restricted Progenitors and Derived Astrocytes into a Contusion Model of Spinal Cord Injury. Jin Y, Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli JT, Fischer I. J Neurotrauma. 2011 Mar 24. [Epub ahead of print]
  8. Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neurological disorders. Sandrock RW, Wheatley W, Levinthal C, Lawson J, Hashimoto B, Rao M, Campanelli JT. Regen Med. 2010 May;5(3):381-94
  9. Lepore et al (2008) Focal tranplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease, Nature Neuroscience, 11 (11): 1294-1301
  10. Windrem et al (2008) Neonatal chimerization with human glial progenitor cells can both remylinate and rescue the otherwise lethally hypomyelinated shiverer mouse, Cell Stem Cell, 2; 553-565
  11. Campanelli et al (2008)  Expression profiling of human glial precursors.  BMC Developmental Biology 8: 102 http://www.biomedicalcentral.com/ 1471-213X/8/102
  12. Lepore et al (2006) Long-term fate of neural precursor cells following transplantation into developing and adult CNS, Neuroscience, 139: 516-530
  13. Kaplin et al (2005) IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis, J. Clinical Investigation, 115 (10): 2731-2741
  14. Lepore et al (2005) Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord, Brain Research, 1045: 206 - 216
  15. Mitsui et al (2005) Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity , and modifies intraspinal circuitry, J. Neuroscience, 25(42): 9624-9636
  16. Totoiu et al (2004) Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of Multiple Sclerosis, Exp Neurol, 187: 254-265
  17. Windrem et al (2004) Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain, Nature Medicine, 10(1): 93 - 97

Scientific Reviews
 
  1. Krishnan et al (2006) Demyelinating Disorders: Update on Transverse Myelitis, Current Neurology and Neuroscience Reports, 6: 236-243
  2. Frederick & Miller (2006) Future of multiple sclerosis therapy: combining antigen-specific immunotherapy with strategies to promote myelin repair, Future Neurology, 1(4): 489-503
  3. Magnus and Rao (2005) Neural stem cells in inflammatory CNS diseases: mechanisms and therapy, J. Cellular and Molecular Medicine, 9(2): 303-319.
  4. Goldman (2005) Stem and progenitor cell-based therapy of the human central nervous system,Nature Biotechnology, 23(7): 862-871
  5. Krishnan et al (2004) Transverse myelitis: pathogenesis, diagnosis, and treatment, Frontiers in BioScience, 9: 1483-1499
Q-Cells do not differentiate into neurons, eliminating the risk of uncontrolled new neuron formation or aberrant neuronal connections that could lead to seizures or other nerve conduction problems. In addition, Q-Cells can be injected directly into the brain or spinal cord at the site of injury or disease, avoiding many of the off-target risks associated with oral medicines or medicines delivered through the bloodstream.